iNEW

internationalNeurovascularExploratoryWorkshop – iNEW’2018

a translational effort involving a balanced mix of engineers, biologists and medical doctors

CABMM, Z?rich – February 7-9, 2018

Vessel wall inflammation in intracranial aneurysms: Role of biology, biomechanics and imaging

The severity of the intracranial aneurysm disease:

When performing cross-sectional brain imaging studies in healthy adults, in approximately 10%, there will be signs of pending neurovascular disease at a stage where often only minimal, preventive measures may allow for averting from damaging ischemic or hemorrhagic stroke events or development of vascular dementia. Rarely, that is in about 2-3%, there will be a finding of an intracranial aneurysm that warrants further imaging investigations and possibly a preemptive endovascular or surgical invasive treatment.

Aneurysm disease?is a degenerative disease of the vessel wall, initiated at a weak spot and undergoing successive steps of further destructive remodeling of the wall. With active processes of destructive remodeling, the aneurysm wall may be instable, allowing for an aneurysm to grow and being exposed to an increased risk of rupture.

Changing disease understanding: Vessel wall inflammation in intracranial aneurysm:

Disease understanding of initiation and growth of intracranial aneurysms and mechanisms of aneurysm wall destabilization have evolved and similar to aortic aneurysm disease and to atherosclerosis, chronic and acute inflammation processes have become the focus of current research efforts.

Confirming the role of inflammation, developing the specific diagnostic capabilities of aneurysm wall inflammation and drafting concepts on how to overcome such localized chronic and acute inflammation would all be contributing to translating current knowledge from different fields, and where required, allowing for defining missing specific elements to be addressed.

Such a translational effort is in the interest of the increasingly incidentally identified patients exhibiting an unruptured aneurysm, where always the question arises, whether there is a stable or instable condition of the lesions – whether there is need to recommend a potentially harmful and expensive treatment. Any progress in the matter is likely to improve counseling and care of concerned patients. Treatment of unruptured aneurysm should be limited to unstable lesions and novel options could possibly be developed and investigated to alleviate from inflammation related destructive remodeling.

Stabilization of the aneurysm wall may proof to be key and sufficient, when it comes to future management of the majority of incidentally discovered aneurysms.

The multidisciplinary setting in view of designing novel approaches and methodologies:

Together with the CABMM associated experts in the field, we intent to gather complementary international and national experts of potentially concerned disciplines. In a 3-day workshop, current knowledge and existing know-how would be assessed. Presentations and discussion will occur in a setting, where moderators will look for obtaining expert answers to questions.

The exploratory workshop, designed as an interdisciplinary meeting and aiming at a translational approach is in our view promising to reach a common ground on how to tackle the ambition of governing derailed biological processes and to develop methodologies to test biologically active treatment.

The workshop will be advertised by CABMM and will be open at no cost to young researchers in the field.

Dr. Katja Nuss

Deputy Facility Management

Study Director

Experimental Surgery

Musculoskeletal Research Unit

Vetsuisse Fakult?t

Zurich University